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威尼斯网站大全-澳门威利斯v9579网

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  • ????????0.25g*10?
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104593 ?????
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???0.25g*10? /
5300
  *???????????????????ο??????????????????????

?????????????????????(?????????) ??Ч????????????????????????????????????ù????????????????????????(?????????)??Ч??

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????????????????????????????????????????????С????????NSCLC????????????????????????????????????????
???????????????????????????С?????????????Ч??????????????????????????????????о?????????????????????????????????????档??????????С?????????????????????????????????????о????д????????????????????????????
?????С????????????????????????????????????????????????????????????????????????????????δ????κ????棬??????????????????????????

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????????????????????????????????(EGFR)????????????????????????????????????????
????????????????????????????????????????????????????????ɡ????????????????????????????????????????????????????????????????????????????о?????????????????????????????????????????????????
????о? ????????II??????о????????????????????????????????С??????(NSCLC)????Ч?????????????WHO????????????0-2????????????????????????
IDEAL1(?о?0016)????????????1??2????????????????????????????????????(??λ?????59.6??[28-85??]??n??209)??
IDEAL2(?о?0039)????????????2??????????????????????????????????????????????????????????(??λ?????61??[30-84??]??n??216)??
?????о????????????????????顢?????????????????????????????????250mg/???500mg/???????????????????????????顣??IDEAL1??????о??????????????????????о?????????????????????IDEAL2??????о???????????????????????????????????(?????LCS???в?)??
??Ч??? ????IDEAL1??IDEAL2??Ч??????????±?????????WHO???????????(0,1??2)???????????????????????о??е??????????????????????????????????????????????????????????????????????1?????????????????????????????4???·?????
a ??IDEAL1?????У???????250mg????500mg??????????????????????????????(250mg?27.5%??9.6%??500mg?27.5%??11.1%)??δ??????????(??????)?3.27??p=0.002??????????????????????????????????????????????????????????(????????????2.13??p=0.068)??
b ??????????????????(250mg??n=67??500mg??n=73)??
????????????????
FACT-L???????????????????????
NCδ????
PFS???????档
????? ?????????????????????о?????????????????????????????????????????(??[???????])??
???? ????о??????????????????????С??????????????????????????????????????
???й????е?????о? ???й???5??????о??????н?????????о??????????????????250mg/?????????????????????С???????????е?????????
????159???????????????????μ????????250mg??????????????????????????????
????91??(57.2)?????68??(42.8)??
???????(?????)?56.5??(11.3)????λ???57????Χ(??С???????)??31.0-84.0??
???????????18-60??????91??(57.2%)??60-70??????46??(28.9%)??70??????????22??(13.8%)??
???????????????????90??(56.6%)????????????37??(23.3%)?????????????3??(1.9%)??????????????29??(18.2%)??
??????????????29??(18.2%)???????105??(66%)??δ???????5??(3.1%)???????????1??(0.6%)?????????7??(4.4%)????????????(BAC)??12??(7.5%)??
??????С?????????????????MO??26??(16.4%)???????M1??133??(83.6%)??
WHO?????????0????23??(14.5%)??1????101??(63.5%)??2????34??(21.4%)??3????1??(0.6%)??
?????????????????1??????????????????????75??(47.2%)??2????3??????(??3??)?????????????????????50??(31.4%)??34??(21.4%)??????159????????(???????????????)????????Ч???????
???????Ч???
?????????27.0%??
95%?????????20.3-34.7%??
??λPFS?97??
95%?????????67-120??
??λ???????11.1?????????????????2004??11??22?????
?????????????п??????????????????????(????????????????????з??飬????????????????????±????????????????????????????????о??????????Щ????????????????????????????????Щ???????Ч??????????????

???????????????á?
????????????е???????????????????????????????????P-450???CYP 3A4??л?????????????????????????????????????л????????????á??????о????????????????????????????????о??????????????????????CYP 2D6??
?????г????????????????????????????????????????????????????
?????????????????????????? - ????CYP3A4???????????????н???????????????????(???CYP 3A4?????)?????????????????AUC????80?????????????????????????????????????????????????塣???δ??????????CYP 3A4?????????????о?????????????????????ù????????Τ????????????????????л??
????θpH????????????????н???????о??????????????????????θpH???? (greater than or equal to) 5????????????????????????AUC????47?????????????????????Ч??
?????????????????н????????????????(??????CYP 3A4?????)?????????????????AUC??????????83????
????????????????????? - ????CYP 3A4??????????CYP 3A4???????????????????????л?????????????????????CYP 3A4?????(?籽??????????????????????????)??????????Ч??
??????????????????????????????????? - ???CYP 2D6??л??????????????????У??????????????????(???CYP 2D6?????)???????????????????????35????????????????????CYP 2D6??л?????????????????????????????
????????????????????? - ????????????????δ???????????????????о??????Щ??????????????б?????INR?????/????????????????????????????????????????INR????

?????????
???????????400-693-1193
??????????????????????????????????????????
???????: 8:00-21:00
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威尼斯网站大全|澳门威利斯v9579网

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